Firstly, correcting for multiple comparisons decreases

Correction for multiple comparisons decreases the risk of false positives, but does not eliminate the broader problem. Firstly, correcting for multiple comparisons decreases statistical power, thus increasing the risk of false negative findings further. Secondly, as investigators add subgroup analyses with less and less evidence or theory to support them, the prior probability for the average subgroup analysis inevitably falls, further reducing the positive predictive value (fig 2)..

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